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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 343989, 5 pages
Research Article

Biocompatibility Evaluation of a New Hydrogel Dressing Based on Polyvinylpyrrolidone/Polyethylene Glycol

1Department of Chemistry, Tonekabon branch, Islamic Azad University, Tonekabon, Iran
2Young Researchers Club, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Nuclear Agriculture Research Department, Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Institute, Iran
4Department of Microbiology, Tonekabon branch, Islamic Azad University, Tonekabon, Iran
5Young Researchers Club, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran

Received 27 March 2011; Revised 22 June 2011; Accepted 23 June 2011

Academic Editor: Masa-Aki Shibata

Copyright © 2012 Esmaeil Biazar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The composition of the dressings is based on polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), and agar. The electron beam irradiation technique has been used to prepare hydrogel wound dressings. The in vitro biocompatibility of the hydrogel was investigated by check samples (hydrocolloid Comfeel), antibacterial test (Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia Coli k12), anti fungal test (Candida Albicans) and cytotoxicity test (Fibroblast L929). Results have shown cell attachment characteristics and nontoxicity of all samples. Antibacterial testing also showed that the antibacterial effect of the hydrogel sample to the check sample increased to 30%. Also, investigation of antifungal analysis did not show any trace of fungi growth on the surface of the hydrogel, whereas antifungal effect did not observe on the surface of the check sample. Finally, this hydrogel sample showed a good in vitro biocompatibility.