Multiple Signaling Pathways Are Involved in the Interleukine-4 Regulated Expression of DC-SIGN in THP-1 Cell Line
Figure 6
Signaling pathways involved in IL-4-induced DC-SIGN expression on THP-1 cells. ERK signaling pathway plays a main role by transcription factor of Ets-1 to active DC-SIGN promoter. JAK-STAT and NF-κB signaling pathways are also involved, which may be induced by IL-4/IL-4R directly or by the interactions with ERK pathway indirectly.
