BioMed Research International

Research Article

The Difference in Pharmacokinetics and Pharmacodynamics between Extended-Release Fluvastatin and Immediate-Release Fluvastatin in Healthy Chinese Subjects

Table 1

Pharmacokinetic parameters of fluvastatin of two fluvastatin formulations after single and multiple doses in healthy volunteers (Mean ± SD).
ParameterTest (extended-release tablet)Reference (immediate-release capsule)
Single dose 𝐶 m a x (ng/mL) 6 1 . 0 ± 3 9 . 0 2 8 3 ± 2 7 1
𝑇 m a x (h) 2 . 5 0 ± 1 . 3 4 0 . 7 8 ± 0 . 3 8
MRT (h) 4 . 9 8 ± 2 . 2 8 1 . 4 5 ± 0 . 4 4
AUC0-24 (ng·h/mL) 2 4 2 ± 1 5 6 7 2 0 ± 7 7 6
𝐹 (%) 4 5 . 3 ± 2 3 . 9
Multiple doses 𝐶 m a x (ng/mL) 6 3 . 9 ± 2 9 . 7 3 8 2 ± 2 5 5
𝐶 m i n (ng/mL) 1 . 9 4 ± 4 . 1 6 0 . 5 7 4 ± 1 . 6 3
𝐶 a v (ng/mL) 1 2 . 2 ± 7 . 7 6 5 2 . 5 ± 4 5 . 2
𝑇 m a x (h) 2 . 6 0 ± 0 . 8 7 0 . 8 8 ± 0 . 3 6
MRT (h) 5 . 5 7 ± 2 . 4 0 1 . 4 3 ± 0 . 3 0
AUC0-24 (ng·h/mL) 2 5 3 ± 9 1 . 1 9 1 7 ± 9 9 4
𝑅 1 . 3 9 ± 0 . 7 7 2 . 0 7 ± 1 . 4 2
DF (%) 5 6 6 ± 2 1 4 8 1 1 ± 2 1 3
𝐹 (%) 4 3 . 3 ± 2 4 . 1