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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 412486, 11 pages
Review Article

SPECT Molecular Imaging in Parkinson's Disease

Ling Wang,1,2,3,4,5 Qi Zhang,2 Huanbin Li,2 and Hong Zhang1,3,4,5

1Department of Nuclear Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China
2Department of Nuclear Medicine, Wenzhou Medical College, Wenzhou, China
3Zhejiang University Medical PET Center, Zhejiang University, Hangzhou, China
4Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China
5Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

Received 3 January 2012; Accepted 29 January 2012

Academic Editor: Mei Tian

Copyright © 2012 Ling Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Parkinson's disease (PD) is a common disorder, and the diagnosis of Parkinson's disease is clinical and relies on the presence of characteristic motor symptoms. The accuracy of the clinical diagnosis of PD is still limited. Functional neuroimaging using SPECT technique is helpful in patients with first signs of parkinsonism. The changes detected may reflect the disease process itself and/or compensatory responses to the disease, or they may arise in association with disease- and/or treatment-related complications. This paper addresses the value of SPECT in early differential diagnosis of PD and its potential as a sensitive tool to assess the pathophysiology and progression, as well as the therapeutic efficacy of PD.