The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics: A Paired Analysis

Table 1

Clinical characteristics and pharmacokinetic estimates for intravenous paracetamol (single dose, 2 g) in 8 women as collected at delivery and in postpartum (10–15 weeks after delivery). Data provided by median and range.

	At delivery	Postpartum	𝑃 value
Body weight (kg)	78.5 (61–92.2)	69 (52.2–88)	𝑃=0.0078
Body surface area, BSA (m^2)	1.96 (1.65–2.06)	1.83 (1.51–2.01)	𝑃=0.0078
Clearance (L/h)	22.19 (13.08–27.32)	11.31 (8.06–15.72)	𝑃=0.0078
Clearance (L/h·kg)	0.29 (0.2–0.32)	0.17 (0.15–0.2)	𝑃=0.0078
Clearance/BSA (L/h·m^2)	11.7 (7.7–13.3)	6.4 (5.3–7.8)	𝑃=0.0078
Distribution volume (L)	61.7 (43.5–75)	35.7 (29.5–59.3)	𝑃=0.0234
Distribution volume (L/kg)	0.77 (0.7–0.87)	0.59 (0.35–0.85)	n.s.
Elimination half-life (h)	1.9 (1.8–2.5)	2.3 (1.4–3.6)	n.s.