|
| Deacetylase | Accession numbers | Class | Subcelullar localization | Comments |
Reference |
| T. brucei | L. major | T. cruzi |
|
| DAC1 | Tb10.70.6220 | LmjF21.0680 | Tc00.1047053511911.159 Tc00.1047053508637.114 | I | Predominantly nuclear proteins in bloodstream form and citoplasmatic in the insect stage (T. brucei) | Antagonizes SIR2rp1-dependent telomeric silencing essential for viability | Ingram and Horn, 2002 [46]
Wang et al., 2010 [47] |
| DAC2 | Tb11.01.7240 | | Tc00.1047053504159.80 Tc00.1047053506821.140 | I | Citoplasmatic (T. brucei) | Not essential for viability | Ingram and Horn, 2002 [46] |
| DAC3 | Tb927.2.2190 | LmjF21.1870 | Tc00.1047053509395.120 Tc00.1047053503653.50 | II | Nuclear in all life cycle stages (T. brucei) | Specifically required for silencing at VSG ES promoters in both bloodstream and insect-stage cells essential for viability | Ingram and Horn, 2002 [46]
Wang et al., 2010 [47] |
| DAC4 | Tb927.5.2900 | LmjF08.1090 | Tc00.1047053507063.270 | II | Citoplasmatic (T. brucei) | Not essential for viability | Ingram and Horn, 2002 [46] |
| SIR2RP1 | Tb927.7.1690 | LmjF26.0210 | Tc00.1047053507519.60 Tc00.1047053508207.150 | III | Citoplasmatic in promastigote y amastigote stages (L. major, L. amazonensis, and L. infantum) | Deacetylates α-tubulin and is partially associated with the microtubule network | Yahiaoui et al., 1996 [48] Tavares et al., 2008 [49] |
| Nuclear in all life cycle stages (T. brucei) | Catalyzes ADP ribosylation and deacetylation of histones is involved in DNA repair |
García-Salcedo et al., 2003 [50]
Alsford et al., 2007 [51] |
| SIR2RP2 | Tb927.8.3140 | LmjF23.1210 | | III | Mitocondrial (T. brucei) | |
Alsford et al., 2007 [51] |
| SIR2RP3 | Tb927.4.2520 | LmjF34.2140 | Tc00.1047053447255.20 Tc00.1047053506559.80 | III |
|
