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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 462543, 12 pages
Review Article

Adipose Tissue Regeneration: A State of the Art

1Casadei Clinic, Via Olimpia 9, Mestre, 30174 Venezia, Italy
2Bioscience Institute, Via Rovereta 42, Falciano, 47891 San Marino, Italy
3Department of Biomedical Sciences, University of Padova, Via G. Colombo 3, 35100 Padova, Italy
4Department of Neurosciences, University of Padova, Via Venezia 90, 35100 Padova, Italy
5Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI) and LTTA Center, University of Ferrara, 44121 Ferrara, Italy

Received 5 June 2012; Revised 7 July 2012; Accepted 16 July 2012

Academic Editor: Thomas Liehr

Copyright © 2012 Alessandro Casadei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Adipose tissue pathologies and defects have always represented a reconstructive challenge for plastic surgeons. In more recent years, several allogenic and alloplastic materials have been developed and used as fillers for soft tissue defects. However, their clinical use has been limited by further documented complications, such as foreign-body reactions potentially affecting function, degradation over time, and the risk for immunogenicity. Tissue-engineering strategies are thus being investigated to develop methods for generating adipose tissue. This paper will discuss the current state of the art in adipose tissue engineering techniques, exploring the biomaterials used, stem cells application, culture strategies, and current regulatory framework that are in use are here described and discussed.