Table 1: Potential ameliorative effects mediated by MSCs in ASD treatment.

ASD-induced changes in human brainPotential MSC ameliorative roles seen in preclinical models

Abnormal functioningImproving functional recovery
Cerebellum alterationsIntegrating in altered brain and restoring damaged functions
Decreased number of Purkinje cells (PCs)Restoring cerebellar PCs
Defective cortical organizationReinforcing cortical plasticity
Altered plasticity of dendritic spine morphologyPromoting synaptic plasticity