Biological Functions of the Novel Collectins CL-L1, CL-K1, and CL-P1

Table 1

Characteristics of classical collectin and novel collectin.

	Classical collectin			Novel collectin
	MBL	SP-A	SP-D	CL-L1	CL-K1	CL-P1
Chromosomal location; human	10q11.2	10q22.3	10q22.2-q23.1	8q23-q24.1	2p25.3	18pter-p11.3
mouse	MBL-A:14; MBL-C:19	14	14	15	12	18
HUGO; COLEC no.	1	4	7	10	11	12
Localization	Secreted	Secreted	Secreted	Cytoplasmic	Secreted	Membrane
Tissue expression	Liver	Lung	Lung	Ubiquitous	Ubiquitous	Vascular endothelium
Sugar-binding specificities	GlcNAc > Fuc, Man	ManNAc > Fuc, Mal	Mal > Man, Glc	Man, Fuc, Gal	Fuc > Man	Gal, GalNAc, Le^x
Lectin frame	Y-N-EPN-E-	Y-N-EPA-E	Y-N-EPN-E	Y-N-EPS-E-	F-K-EPN-E	Y-N-QPD-E
Binding activity	Strong	Strong	Strong	Weak	Weak	Weak
Biological activities	Innate immunity	Innate immunity	Innate immunity homeostasis of surfactant	Unknown	Innate immunity?; embryogenesis?; structuraldevelopment?	Innate immunity scavenger receptor