Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 507057, 10 pages
http://dx.doi.org/10.1155/2012/507057
Research Article

Troglitazone Induces Extracellular Matrix and Cytoskeleton Remodeling in Mouse Collecting Duct Cells

Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5

Received 16 September 2011; Revised 9 November 2011; Accepted 15 November 2011

Academic Editor: Beric Henderson

Copyright © 2012 Jaime Corinaldi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. S. Chou, P. S. Wang, S. Kulp, and J. J. Pinzone, “Effects of thiazolidinediones on differentiation, proliferation, and apoptosis,” Molecular Cancer Research, vol. 5, no. 6, pp. 523–530, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Han and J. Roman, “Peroxisome proliferator-activated receptor γ: a novel target for cancer therapeutics?” Anti-Cancer Drugs, vol. 18, no. 3, pp. 237–244, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Han, J. D. Ritzenthaler, H. N. Rivera, and J. Roman, “Peroxisome proliferator-activated receptor-γ ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1,” American Journal of Physiology, vol. 289, no. 3, pp. L419–L428, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. U. Panchapakesan, S. Sumual, C. A. Pollock, and X. Chen, “PPARγ agonists exert antifibrotic effects in renal tubular cells exposed to high glucose,” American Journal of Physiology - Renal Physiology, vol. 289, no. 5, pp. F1153–F1158, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Bishop-Bailey and T. D. Warner, “PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist,” FASEB Journal, vol. 17, pp. 1925–1927, 2003. View at Google Scholar
  6. Y. Guan, C. Hao, D. R. Cha et al., “Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption,” Nature Medicine, vol. 11, no. 8, pp. 861–866, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Chen, B. M. Necela, W. Su et al., “Peroxisome proliferator-activated receptor γ promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2,” Journal of Biological Chemistry, vol. 281, no. 34, pp. 24575–24587, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Ivanova, M. J. Butt, and D. G. Matsell, “Mesenchymal transition in kidney collecting duct epithelial cells,” American Journal of Physiology, vol. 294, no. 5, pp. F1238–F1248, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Surendran, S. P. McCaul, and T. C. Simon, “A role for Wnt-4 in renal fibrosis,” American Journal of Physiology, vol. 282, no. 3, pp. F431–F441, 2002. View at Google Scholar · View at Scopus
  10. J. Liu, H. Wang, Y. Zuo, and S. R. Farmer, “Functional interaction between peroxisome proliferator-activated receptor γ and β-catenin,” Molecular and Cellular Biology, vol. 26, no. 15, pp. 5827–5837, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. J. S. Annicotte, I. Iankova, S. Miard et al., “Peroxisome proliferator-activated receptor γ regulates E-cadherin expression and inhibits growth and invasion of prostate cancer,” Molecular and Cellular Biology, vol. 26, no. 20, pp. 7561–7574, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Sharma, A. Pradeep, L. Wong, A. Rana, and B. Rana, “Peroxisome proliferator-activated receptor γ activation can regulate β-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway,” Journal of Biological Chemistry, vol. 279, no. 34, pp. 35583–35594, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Nasrallah, J. Clark, J. Corinaldi et al., “Thiazolidinediones alter growth and epithelial cell integrity, independent of PPAR-γ and MAPK activation, in mouse M1 cortical collecting duct cells,” American Journal of Physiology, vol. 298, no. 5, pp. F1105–F1112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Welbourne, G. Su, G. Coates, R. Routh, K. McCarthy, and H. Battarbee, “Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells,” American Journal of Physiology, vol. 282, no. 6, pp. R1600–R1607, 2002. View at Google Scholar · View at Scopus
  15. Y. Guan, Y. Zhang, L. Davis, and M. D. Breyer, “Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans,” American Journal of Physiology, vol. 273, no. 6, pp. F1013–F1022, 1997. View at Google Scholar · View at Scopus
  16. H. Zhang, A. Zhang, D. E. Kohan, R. D. Nelson, F. J. Gonzalez, and T. Yang, “Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 26, pp. 9406–9411, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. H. C. Cheng, T. C. Ho, S. L. Chen, H. Y. Lai, K. F. Hong, and Y. P. Tsao, “Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells,” Molecular Vision, vol. 14, pp. 95–104, 2008. View at Google Scholar · View at Scopus
  18. C. E. Clay, A. M. Namen, G. I. Atsumi et al., “Magnitude of peroxisome proliferator-activated receptor-γ activation is associated with important and seemingly opposite biological responses in breast cancer cells,” Journal of Investigative Medicine, vol. 49, no. 5, pp. 413–420, 2001. View at Google Scholar · View at Scopus
  19. E. Ito, S. Ozawa, K. Takahashi et al., “PPAR-γ overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein,” Biochemical and Biophysical Research Communications, vol. 324, no. 2, pp. 810–814, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Kanoh, G. Bandyopadhyay, M. P. Sajan, M. L. Standaert, and R. V. Farese, “Thiazolidinedione treatment enhances insulin effects on protein kinase C-ζ/λ activation and glucose transport in adipocytes of nondiabetic and Goto-Kakizaki type II diabetic rats,” Journal of Biological Chemistry, vol. 275, no. 22, pp. 16690–16696, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Yang, C. C. Chan, O. S. Kwon et al., “Regulation of peroxisome proliferator-activated receptor-γ in liver fibrosis,” American Journal of Physiology, vol. 291, no. 5, pp. G902–G911, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Turturro, R. Oliver, E. Friday, I. Nissim, and T. Welbourne, “Troglitazone and pioglitazone interactions via PPAR-γ-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines,” American Journal of Physiology, vol. 292, no. 3, pp. C1137–C1146, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. R. F. Husted, R. D. Sigmund, and J. B. Stokes, “Mechanisms of inactivation of the action of aldosterone on collecting duct by TGF-β,” American Journal of Physiology, vol. 278, no. 3, pp. F425–F433, 2000. View at Google Scholar · View at Scopus
  24. R. F. Husted and J. B. Stokes, “Separate regulation of Na+ and anion transport by IMCD: location, aldosterone, hypertonicity, TGF-β1, and cAMP,” American Journal of Physiology, vol. 271, no. 2, pp. F433–F439, 1996. View at Google Scholar · View at Scopus
  25. M. Desclozeaux, J. Venturato, F. G. Wylie et al., “Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis,” American Journal of Physiology, vol. 295, no. 2, pp. C545–C556, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Masszi, L. Fan, L. Rosivall et al., “Integrity of cell-cell contacts is a critical regulator of TGF-β1-induced epithelial-to-myofibroblast transition: role for β-catenin,” American Journal of Pathology, vol. 165, no. 6, pp. 1955–1967, 2004. View at Google Scholar · View at Scopus
  27. C. Bocca, F. Bozzo, S. Francica, S. Colombatto, and A. Miglietta, “Involvement of PPARγ and E-cadherin/β-catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF-7 cells,” International Journal of Cancer, vol. 121, no. 2, pp. 248–256, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. A. B. Reynolds and R. H. Carnahan, “Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer,” Seminars in Cell and Developmental Biology, vol. 15, no. 6, pp. 657–663, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Drees, S. Pokutta, S. Yamada, W. J. Nelson, and W. I. Weis, “α-catenin is a molecular switch that binds E-cadherin-β-catenin and regulates actin-filament assembly,” Cell, vol. 123, no. 5, pp. 903–915, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Zafiriou, S. R. Stanners, S. Saad, T. S. Polhill, P. Poronnik, and C. A. Pollock, “Pioglitazone inhibits cell growth and reduces matrix production in human kidney fibroblasts,” Journal of the American Society of Nephrology, vol. 16, no. 3, pp. 638–645, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Guo, D. Koya, M. Isono, T. Sugimoto, A. Kashiwagi, and M. Haneda, “Peroxisome proliferator-activated receptor-γ ligands inhibit TGF-β1-induced fibronectin expression in glomerular mesangial cells,” Diabetes, vol. 53, no. 1, pp. 200–208, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. A. C. Calkin, S. Giunti, K. A. Jandeleit-Dahm, T. J. Allen, M. E. Cooper, and M. C. Thomas, “PPAR-α and -γ agonists attenuate diabetic kidney disease in the apolipoprotein E knockout mouse,” Nephrology Dialysis Transplantation, vol. 21, no. 9, pp. 2399–2405, 2006. View at Publisher · View at Google Scholar · View at Scopus