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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 509420, 5 pages
http://dx.doi.org/10.1155/2012/509420
Research Article

Associations of Polymorphisms in the Apolipoprotein APOA1-C3-A5 Gene Cluster with Acute Coronary Syndrome

1Hubei Provincial Key Laboratory of Embryonic Stem Cell Research, Tai He Hospital, Hubei University of Medicine, 32 S. Renmin Road, Shiyan, Hubei 442000, China
2Clinical Laboratory, Tai He Hospital, Hubei University of Medicine, 32 S. Renmin Road, Shiyan, Hubei 442000, China
3Cardiovascular Department, Taihe Hospital, Hubei University of Medicine, 32 S. Renmin Road, Shiyan, Hubei 442000, China

Received 10 February 2012; Revised 8 March 2012; Accepted 22 March 2012

Academic Editor: Momiao Xiong

Copyright © 2012 Yan Ding et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Acute coronary syndromes (ACSs) are clinically cardiovascular events associated with dyslipidemia in common. Single nucleotide polymorphisms (SNPs) and haplotypes in the APOA1/C3/A5 gene cluster are associated with diabetes and familial combined hyperlipidaemia (FCH). Little is known about whether the polymorphisms in these genes affect lipid homeostasis in patients with ACSs. The present paper aimed to examine these associations with 4 SNPs in the APOA1 −75 G > A , the APOC3 −455 T > C , and APOA5 −1131 T > C , c.553 G > T variant to ACSs in Chinese Han. Methods. Chinese Han of 229 patients with ACSs and 254 unrelated controls were analyzed. Four SNPs in APOA1/C3/A5 cluster were genotyped and lipid was determined. Results. Our data show that minor allelic frequencies of APOC3 −455 T > C , APOA5 −1131 T > C , and c.553 G > T polymorphisms in patients with ACSs were significantly higher than control group ( 𝑃 < 0 . 0 5 ). Furthermore, the 3 polymorphic sites were strongly of linkage disequilibrium, and minor alleles of 3 SNP sites had higher TG level than wild alleles ( 𝑃 < 0 . 0 5 ), APOC3 −455C and APOA5 c.553T allele carriers also had lower level of HDL-C. Conclusions. The minor alleles of APOC3 −455 T > C , APOA5 −1131 T > C , and c.553 G > T polymorphisms are closely associated with ACSs.