Research Article

Enzymatic Synthesis of Ampicillin: Nonlinear Modeling, Kinetics Estimation, and Adaptive Control

Figure 4

Simulation resultsβ€”exact linearizing control law. The closed loop system was tested for a step profile of the ampicillin concentration reference. Panel (a) shows the time evolution of πœ‰ 1 = 𝑆 1 , πœ‰ 2 = 𝑆 2 , πœ‰ 3 = 𝑃 1 , and πœ‰ 5 = 𝑃 3 (i.e., 6-APA, PGME, PG, and methanol concentrations, resp.). In panel (b), the profiles of specific reaction rates πœ‡ 1 , πœ‡ 2 , and πœ‡ 3 are depicted. Panel (c) presents the output 𝑦 = 𝑃 2 (ampicillin concentration) versus the reference profile 𝑦 βˆ— = 𝑃 βˆ— 2 . Panel (d) shows the control action, that is, the evolution of the dilution rate.
512691.fig.004a
(a)
512691.fig.004b
(b)
512691.fig.004c
(c)
512691.fig.004d
(d)