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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 535361, 6 pages
http://dx.doi.org/10.1155/2012/535361
Research Article

Comprehensive Evaluation of Different T-Helper Cell Subsets Differentiation and Function in Rheumatoid Arthritis

Department of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, China

Received 14 March 2012; Revised 21 May 2012; Accepted 5 June 2012

Academic Editor: Soldano Ferrone

Copyright © 2012 Junwei Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Raychaudhuri, E. F. Remmers, A. T. Lee et al., “Common variants at CD40 and other loci confer risk of rheumatoid arthritis,” Nature Genetics, vol. 40, no. 10, pp. 1216–1223, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Nishimura, D. Sugiyama, Y. Kogata et al., “Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis,” Annals of Internal Medicine, vol. 146, no. 11, pp. 797–808, 2007. View at Google Scholar · View at Scopus
  3. V. Majithia and S. A. Geraci, “Rheumatoid arthritis: diagnosis and management,” American Journal of Medicine, vol. 120, no. 11, pp. 936–939, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Zhu and W. E. Paul, “CD4 T cells: fates, functions, and faults,” Blood, vol. 112, no. 5, pp. 1557–1569, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Gómez-Martín, M. Díaz-Zamudio, J. Romo-Tena, M. J. Ibarra-Sánchez, and J. Alcocer-Varela, “Follicular helper T cells poise immune responses to the development of autoimmune pathology,” Autoimmunity Reviews, vol. 10, no. 6, pp. 325–330, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Dong, P. Zhu, Y. Wang, and Z. Wang, “Follicular helper T cells in systemic lupus erythematosus: a potential therapeutic target,” Autoimmunity Reviews, vol. 10, no. 6, pp. 299–304, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. W. Wang, S. Shao, Z. Jiao, M. Guo, H. Xu, and S. Wang, “The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis,” Rheumatology International, vol. 32, no. 4, pp. 887–893, 2011. View at Google Scholar
  8. M. C. Boissier, E. Assier, G. Falgarone, and N. Bessis, “Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm,” Joint Bone Spine, vol. 75, no. 4, pp. 373–375, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Dardalhon, T. Korn, V. K. Kuchroo, and A. C. Anderson, “Role of Th1 and Th17 cells in organ-specific autoimmunity,” Journal of Autoimmunity, vol. 31, no. 3, pp. 252–256, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. F. M. Brennan and I. B. McInnes, “Evidence that cytokines play a role in rheumatoid arthritis,” Journal of Clinical Investigation, vol. 118, no. 11, pp. 3537–3545, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. F. C. Arnett, S. M. Edworthy, D. A. Bloch et al., “The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis,” Arthritis and Rheumatism, vol. 31, no. 3, pp. 315–324, 1988. View at Google Scholar · View at Scopus
  12. V. P. K. Nell, K. P. Machold, G. Eberl, T. A. Stamm, M. Uffmann, and J. S. Smolen, “Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis,” Rheumatology, vol. 43, no. 7, pp. 906–914, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Morgan, R. Varro, H. Sepulveda et al., “Cytometric bead array: a multiplexed assay platform with applications in various areas of biology,” Clinical Immunology, vol. 110, no. 3, pp. 252–266, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. K. M. Murphy and S. L. Reiner, “The lineage decisions of helper T cells,” Nature Reviews Immunology, vol. 2, no. 12, pp. 933–944, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. H. E. Barksby, S. R. Lea, P. M. Preshaw, and J. J. Taylor, “The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders,” Clinical and Experimental Immunology, vol. 149, no. 2, pp. 217–225, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. D. T. T. Hang, J. Y. Song, M. Y. Kim, J. W. Park, and Y. K. Shin, “Involvement of NF-κB in changes of IFN-γ-induced CIITA/MHC-II and iNOS expression by influenza virus in macrophages,” Molecular Immunology, vol. 48, no. 9-10, pp. 1253–1262, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Palmer, F. Mezin, C. E. Juge-Aubry, C. Plater-Zyberk, C. Gabay, and P. A. Guerne, “Interferon β stimulates interleukin 1 receptor antagonist production in human articular chondrocytes and synovial fibroblasts,” Annals of the Rheumatic Diseases, vol. 63, no. 1, pp. 43–49, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. O. Aravena, B. Pesce, L. Soto et al., “Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-[gamma]-producing NK cell and regulatory T cell subsets,” Immunobiology, vol. 216, no. 12, pp. 1256–1263, 2011. View at Publisher · View at Google Scholar
  19. A. Manzo, S. Paoletti, M. Carulli et al., “Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis,” European Journal of Immunology, vol. 35, no. 5, pp. 1347–1359, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. J. M. Dayer, “Interleukin 1 or tumor necrosis factor-α: which is the real target in rheumatoid arthritis?” Journal of Rheumatology, vol. 29, no. 65, pp. 10–15, 2002. View at Google Scholar · View at Scopus
  21. B. Manoury-Schwartz, G. Chiocchia, N. Bessis et al., “High susceptibility to collagen-induced arthritis in mice lacking IFN-γ receptors,” Journal of Immunology, vol. 158, no. 11, pp. 5501–5506, 1997. View at Google Scholar · View at Scopus
  22. K. Vermeire, H. Heremans, M. Vandeputte, S. Huang, A. Billiau, and P. Matthys, “Accelerated collagen-induced arthritis in IFN-γ receptor-deficient mice,” Journal of Immunology, vol. 158, no. 11, pp. 5507–5513, 1997. View at Google Scholar · View at Scopus
  23. F. Brentano, D. Kyburz, O. Schorr, R. Gay, and S. Gay, “The role of Toll-like receptor signalling in the pathogenesis of arthritis,” Cellular Immunology, vol. 233, no. 2, pp. 90–96, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Chabaud, J. M. Durand, N. Buchs et al., “Human interleukin-17: AT cell-derived proinflammatory cytokine produced by the rheumatoid synovium,” Arthritis & Rheumatism, vol. 42, no. 5, pp. 963–970, 1999. View at Google Scholar
  25. K. Raza, D. Scheel-Toellner, C. Y. Lee et al., “Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis,” Arthritis Research and Therapy, vol. 8, no. 4, article R120, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Fossiez, O. Djossou, P. Chomarat et al., “T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines,” Journal of Experimental Medicine, vol. 183, no. 6, pp. 2593–2603, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Feldmann, F. M. Brennan, and R. N. Maini, “Role of cytokines in rheumatoid arthritis,” Annual Review of Immunology, vol. 14, pp. 397–440, 1996. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Y. A. Hemdan, G. Birkenmeier, G. Wichmann et al., “Interleukin-17-producing T helper cells in autoimmunity,” Autoimmunity Reviews, vol. 9, no. 11, pp. 785–792, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Nakahara, J. Song, M. Sugimoto et al., “Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis,” Arthritis and Rheumatism, vol. 48, no. 6, pp. 1521–1529, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Nishimoto, K. Yoshizaki, N. Miyasaka et al., “Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial,” Arthritis and Rheumatism, vol. 50, no. 6, pp. 1761–1769, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. E. M. Shevach, “From vanilla to 28 flavors: multiple varieties of T regulatory cells,” Immunity, vol. 25, no. 2, pp. 195–201, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. P. J. Cejas, M. C. Walsh, E. L. Pearce et al., “TRAF6 inhibits Th17 differentiation and TGF-β-mediated suppression of IL-2,” Blood, vol. 115, no. 23, pp. 4750–4757, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. C. L. Langrish, Y. Chen, W. M. Blumenschein et al., “IL-23 drives a pathogenic T cell population that induces autoimmune inflammation,” Journal of Experimental Medicine, vol. 201, no. 2, pp. 233–240, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Veldhoen, R. J. Hocking, C. J. Atkins, R. M. Locksley, and B. Stockinger, “TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells,” Immunity, vol. 24, no. 2, pp. 179–189, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. P. R. Mangan, L. E. Harrington, D. B. O'Quinn et al., “Transforming growth factor-β induces development of the T H17 lineage,” Nature, vol. 441, no. 7090, pp. 231–234, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. J. P. Van Hamburg, P. S. Asmawidjaja, N. Davelaar et al., “Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production,” Arthritis and Rheumatism, vol. 63, no. 1, pp. 73–83, 2011. View at Publisher · View at Google Scholar · View at Scopus