Figure 2: Analysis of plasma plasmin activity, tumor cell vascular arrest, and lung retention in mice after inoculation of human tumor cells. Prostate carcinoma PC-hi/diss cells were injected i.v. into wild-type mice (WT) or knock-out mice (KO) lacking plasminogen (Plg). Control wild-type mice did not receive any tumor cells. A group of Plg knock-out (KO) mice received purified plasminogen 1 hr after cell inoculations. Plasma was collected at 24 hr; lung tissue was collected at 2 hr and 24 hr after cell inoculations.