A Novel Antihepatitis Drug, Bicyclol, Prevents Liver Carcinogenesis in Diethylnitrosamine-Initiated and Phenobarbital-Promoted Mice Tumor Model

Table 1

The incidence of liver tumors induced by DEN/PB in mice and the effect of bicyclol determined by H&E staining and histological evaluation.

Group	Dosage; (mg/kg)	HCC	Hepatoma	Cholangioadenoma	Capillary; hemangioma	MBCA
Control	—	0.0 (0/6)	0.0 (0/6)	0.0 (0/6)	0.0 (0/6)	0.0 (0/6)
DEN/PB	—	33.3 (3/9)	55.6 (5/9)	22.2(2/9)	11.1 (1/9)	88.9 (8/9)
Bicyclol	100	11.1 (1/9)	22.2 (2/9)	11.1(1/9)	0.0 (0/9)	33.3 (3/9)
	200	0.0 (0/8)	0.0 (0/8)	0.0 (0/8)	0.0 (0/8)	50.0 (4/8)

HCC: hepatocellular carcinoma; MBCA: multiple bile canaliculi hyperplasia.