Adult Bone Marrow: Which Stem Cells for Cellular Therapy Protocols in Neurodegenerative Disorders?

Table 1

Maturation steps of bone marrow derived neuron-like cells.

Maturation of BMDN	5 Days in vitro	8 Days in vitro	12 Days in vitro
Neurotransmitter sensitivities	GABA, glycine, glutamate	GABA, glycine, glutamate	GABA, glycine, glutamate
Potassic voltage-gated channels	+++	+++	+++
Sodic voltage-gated channels	−	+++	+++
Action potentials	−	+++	+++
Trains of action potentials	−	−	−
Synaptic activities	−	−	−
Membrane potential (mV)	−37±3	−50,3±2	−57,7±2,3