Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

Figure 1

This figure depicts the linear HSV-1 strains 17 Syn+ noting specific regions of the genome. The abbreviations are as follows: TR_L—terminal repeat long; TR_S—terminal repeat short; U_L—unique long; U_S—unique short; IR_L—internal repeat long; IR_S—internal repeat short. Note that LAT is in two regions of the HSV-1 genome (TR_L and IR_L). An 8.5 kb polyadenylated precursor is transcribed. Within the last domain are two very important immediate-early genes, ICP0 and ICP34.5. Also note the promoter, the CAP site, and a 2.0 kb intron. Further modification results in a 1.5 kb smaller intron.