Review Article
Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases
Table 2
Detection of infectious HSV-1 from eye swabs—spontaneous shedding in noninduced mice.
| | Mouse strain | Gender | HSV-1 Strain | Tissue/fluid/identification procedure | Frequency of detection of reactivation | Authors, year (reference no.) |
| | BALB/c (inbred) | Male | McKrae | Ocular swabs | 3/97 (3%) | Willey et al., 1984 [44];
Laycock et al., 1991 [112] | | ICR (Harlem outbred) | Male | Patton | Explant TG | 6/22 (27%); 14 hr time period | Pesola et al., 2005 [113] | | ICR (Harlem) | Male | KOS | Explant TG | 1/20 (5%); 2 hr time period | Pesola et al., 2005 [113] | | ICR (Harlem) | Male | KOS | Explant TG | 4/18 (22%); 14 hr time period | Pesola et al., 2005 [113] | | NIH-OLA (inbred) | NA | McKrae | Eye wash | 1/11 (9%) | Shimeld et al., 1990 [42] | | Swiss Webster (outbred) | Male | 17 Syn+ | TG homogenized | 1/23 (4%); PI day 31 | Sawtell 2003 [46] | | Swiss Webster (outbred) | Male | 17 Syn+ | TG homogenized | 1/16 (6%); PI day 60 | Sawtell 2003 [46] |
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NA: not Available and PI: postinoculation.
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