Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

Table 4

Inhibition of induced HSV-1 reactivation in latent mice after stimulation.

Mouse strain	Gender	HSV-1 strain	Inhibitor	Frequency of detection with inhibitor	Frequency of detection without inhibitor	Type or method of induction	Authors, year (Reference no.)
BALB/c	NA	McKrae	Propranolol	12/37 (32%)	20/31 (65%)	Hyperthermia	Gebhardt and Kaufman, 1995 [62]
BALB/c	Female	McKrae	Anti-IL-6 antibodies	6/20 (30%)	14/20 (70%)	Hyperthermia	Kriesel et al., 1997 [114]
BALB/c	Female	McKrae	Anti-IL-6 antibodies	2/20 (20%)	6/8 (75%)	UVB	Kriesel et al., 1997 [114]
BALB/c	Female	McKrae	ACV	20/50 (40%)	39/50 (78%)	Hyperthermia	Gebhardt et al., 2004 [61]
BALB/c	NA	McKrae	ASA	5/36 (14%)	11/36 (31%)	Hyperthermia	Gebhardt et al., 2004 [56]
BALB/c	Female	McKrae	Celecoxib	11/47 (23%)	28/52 (54%)	Hyperthermia	Gebhardt et al., 2005 [115]
BALB/c	Female	McKrae	Bromfenac eye drops	10/24 (41.7%)	16/22 (72.2%)	Cx, Dx & hyperthermia	Higaki et al., 2009 [58]
BALB/c	NA	W strain	Alpha blockers	2/34 (6%)	10/39 (29%)	Epinephrine iontophoresis	Gordon et al., 1990 [90]

ACV: acycloguanosine, ASA: aspirin, and NA: not available.