Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

Table 5

Spontaneous shedding of infectious HSV-1 in latent rabbits.

HSV-1 strain	Tissue/fluid/identification/procedure	Frequency of detection of reactivation	Authors, year (reference no.)
Rodanus	Ocular swabs	31/40 (77%) between 31 and 100 days PI	Laibson and Kibrick,1969 [67]
McKrae	Ocular swabs	13/20 (65%)	Nesburn et al., 1967 [68]
McKrae	Ocular swabs	19/20 (95%)	Kwon et al., 1981 [9]
McKrae	Ocular swabs	2/10 (20%)	Kwon et al., 1982 [73]
McKrae	Ocular swabs	3/20 (15%)	Hill et al., 1983 [74]
Rodanus	Ocular swabs	1/3	Laibson and Kibrick,1966 [75]
McKrae	Ocular swabs	4/68 (5.8%)	Hill et al., 1987 [81]
McKrae	Ocular swabs	6/140 (4%)	Haruta et al., 1987 [10]
McKrae	Ocular swabs	28/216 (13%)	Kaufman et al., 1996 [80]
17 Syn+	Ocular swabs	31/264 (11.7%)	Kaufman et al., 1996 [80]
McKrae	Ocular swabs	10/610 (1.6%)	Beyer et al., 1989 [83]
McKrae	Ocular swabs	4/14(29%)	Beyer et al., 1990 [84]
W Strain	Ocular swabs	11/16 (69%)	Gordon et al., 2003 [15]
McKrae	Ocular swabs	14/20 (70%)	Myles et al., 2003 [86]
McKrae	Ocular swabs	6/16 (38%)	Hill et al., 1997 [87]
McKrae	Ocular swabs	13/20 (65%)	Myles et al., 2004 [89]