Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

Table 6

induction of HSV-1 reactivation in latently infected rabbits.

HSV-1 strain	Type or method of induction	Frequency of detection of reactivation	Use of model	Authors, year (reference no.)
McKrae	Epinephrine iontophoresis	21/28 (75%) of eyes	Experimental induction	Kwon et al., 1981 [9]
McKrae	Epinephrine iontophoresis	9/10 (90%)	Experimental induction	Kwon et al., 1982 [73]
McKrae	Epinephrine iontophoresis	15/20 (75%)	Experimental induction	Hill et al., 1983 [74]
Rodanus	Intramuscular epinephrine	4/6	Experimental induction	Laibson and Kibrick, 1966 [75]
Rodanus	Intramuscular epinephrine	12/22	Experimental induction	Laibson and Kibrick, 1967 [76]
McKrae	Dextro- versus levoepinephrine iontophoresis	5/5 (100%) with 0.01% both levo and dextro	Experimental induction	Hill et al., 1985 [72]
McKrae	Dextro- versus levoepinephrine iontophoresis	with 0.005% epi, 5/10 (50%) with dextro, 10/10 (100%) with levo	Experimental induction	Hill et al., 1985 [72]
McKrae	Iontophoresis of 6-HD with topical epinephrine	17/17 (100%) with both, 6/10 (60%) with epinephrine; 6/12 (50%) with 6-HD	Experimental induction	Shimomura et al., 1983 [71]
McKrae	Timolol 0.01% iontophoresis	18/18 (100%)	Experimental induction	Hill et al., 1987 [81]
McKrae	6-HD iontophoresis followed by topical 5% timolol	12/12 (100%)	Experimental induction	Hill et al., 1987 [81]
McKrae	Mechanical stimulation of TG	10/12 (83%)	Experimental induction	Nesburn et al., 1977 [77]; 1976 [78]
McKrae	Electrical induction of TG	19/23 (83%) of stimuli	Experimental induction	Green et al., 1981 [79]
McKrae	RK reactivation	15/140 (11%)	Reproduce induction in animal model	Haruta et al., 1987 [10]
McKrae	PKP	2/10 (20%)	PKP induction of reactivation	Beyer et al., 1989 [83]
McKrae	PKP and immunosuppression	9/11 (82%)	PKP induction of reactivation	Beyer et al., 1989 [83]
17Syn+	BN52021	9/10 (90%)	Cryogenic induction with lipoxygenase pathway inhibitor	Beyer et al., 1989 [83]
McKrae	Cx and Dx	21/24 (88%)	Induction	Haruta et al., 1989 [88]
McKrae	Cryogenic injury	5/7 (71%)	Induction by corneal nerve disruption	Beyer et al., 1990 [84]
McKrae	Anterior superficial keratectomy	8/12 (67%)	Induction by corneal nerve disruption	Beyer et al., 1990 [84]
McKrae	Transsection at corneoscleral limbus	8/12 (67%)	Induction by corneal nerve disruption	Beyer et al., 1990 [84]
W Strain	Xalatan	18/24 (75%)	Induction	Gordon et al., 2003 [15]
McKrae	Nicotine transdermal	20/20 (100%)	Induction	Myles et al., 2003 [86]
McKrae	Antinerve growth factor antibody	15/16 (93%)	Experimental induction	Hill et al., 1997 [87]
McKrae	Bupropion	20/20 (100%)	Inhibition of nicotine reactivation	Myles et al., 2004 [89]

Cx: cyclophosphamide, Dx: dexamethasone, PKP: penetrating keratoplasty, and RK: radial keratotomy.