Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria

Figure 1

Time-kill curves of MIC of silibinin alone and its combination with MIC₅₀ of ampicillin or gentamicin against S. mutans, S. sanguinis, S. sobrinus, S. anginosus, S. criceti, and S. ratti. Bacteria were incubated with silibinin (•), silibinin + ampicillin (∘), and silibinin + gentamicin (▾) over time. Data points are the mean values ± S.E.M. of six experiments. CFU: colony-forming units.

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