Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria
Time-kill curves of MIC of silibinin alone and its combination with MIC50 of Amp or Gen against S. gordonii, A. actinomycetemcomitans, F. nucleatum, P. intermedia, and P. gingivalis. Bacteria were incubated with silibinin (•), silibinin + Amp (∘), and silibinin + Gen (▾) over time. Data points are the mean values ± S.E.M. of six experiments. CFU: colony-forming units.
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