BioMed Research International / 2012 / Article / Tab 3

Research Article

Synergistic Antibacterial Effect between Silibinin and Antibiotics in Oral Bacteria

Table 3

Synergistic effects of the silibinin with gentamicin against oral bacteria.

StrainsAgentMIC/MBC (μg/mL)FICFICI2Outcome
AloneCombination1

S. mutans ATCC 251753Silibinin0.2/0.40.05/0.10.25/0.250.5/0.5Synergistic/synergistic
Gentamicin8/162/40.25/0.25
S. sanguinis ATCC 10556Silibinin0.4/0.40.1/0.20.25/0.50.375/0.75Synergistic/additive
Gentamicin64/648/160.125/0.25
S. sobrinus ATCC 27607Silibinin0.4/0.80.05/0.20.125/0.250.375/0.5Synergistic/synergistic
Gentamicin4/81/20.25/0.25
S. ratti KCTC 32944Silibinin0.8/0.80.2/0.40.25/0.50.5/0.625Synergistic/additive
Gentamicin16/324/40.25/0.125
S. criceti KCTC 3292Silibinin0.8/1.60.2/0.40.25/0.250.375/0.375Synergistic/synergistic
Gentamicin8/161/20.125/0.125
S. anginosus ATCC 31412Silibinin0.8/1.60.2/0.20.25/0.1250.375/0.375Synergistic/synergistic
Gentamicin32/324/80.125/0.25
S. gordonii ATCC 10558Silibinin0.1/0.20.025/0.050.25/0.250.375/0.5Synergistic/synergistic
Gentamicin32/324/80.125/0.25
A. actinomycetemcomitans ATCC 43717Silibinin1.6/3.20.4/0.80.25/0.250.5/0.5Synergistic/synergistic
Gentamicin4/81/20.25/0.25
F. nucleatum ATCC 51190Silibinin3.2/6.40.8/1.60.25/0.250.5/0.5Synergistic/synergistic
Gentamicin2/40.5/10.25/0.25
P. intermedia ATCC 25611Silibinin1.6/3.20.4/0.80.25/0.250.5/0.375Synergistic/synergistic
Gentamicin16/324/40.25/0.125
P. gingivalis ATCC 33277Silibinin0.8/0.80.1/0.20.125/0.250.375/0.375Synergistic/synergistic
Gentamicin256/51264/640.25/0.125

1The MIC and MBC of the silibinin with gentamicin.
2 The fractional inhibitory concentration index (FIC index).
3American Type Culture Collection (ATCC).
4Korean collection for type cultures (KCTC).

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