Research Article

Triiodothyronine Represses MUC5AC Expression by Antagonizing Sp1 Binding to Its Promoter in Human Bronchial Epithelial HBE16 Cells

Figure 2

T3 inhibits the transcription of MUC5AC in HBE16 cells. The luciferase activity was determined as described in Materials and Methods. Control group: different MUC5AC promoter plasmids in the absence of T3; experimental group: different MUC5AC promoter plasmids in the presence of T3. 𝑃 < 0 . 0 1 versus pGL3-basic control group; 𝑃 > 0 . 0 5 versus pGL3-basic control group; # 𝑃 > 0 . 0 5 versus the same promoter control group; ## 𝑃 < 0 . 0 1 versus the same promoter control group.
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