Figure 2: Possible mechanism of human osteoclastogenesis by peptide A and antibodies against TCTA protein. (Structure of TCTA is derived from SOSUI; http://bp.nuap.nagoya-u.ac.jp/sosui/sosui_submit.html). TCTA protein plays an important role in cellular fusion in human osteoclastogenesis from monocytes and mature osteoclasts. Both peptide A and antibodies block the interaction between TCTA protein and a putative counterpart of TCTA protein.Modified from the figure in [11].