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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 692609, 11 pages
Review Article

Animal Models of Glaucoma

1Department of Ophthalmology, Summa Health System, Akron, OH 44304, USA
2Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21210, USA
3Research Department, King Khaled Eye Specialist Hospital, P.O. Box 7191, Riyadh 11462, Saudi Arabia

Received 16 January 2012; Revised 27 February 2012; Accepted 29 February 2012

Academic Editor: Monica Fedele

Copyright © 2012 Rachida A. Bouhenni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Glaucoma is a heterogeneous group of disorders that progressively lead to blindness due to loss of retinal ganglion cells and damage to the optic nerve. It is a leading cause of blindness and visual impairment worldwide. Although research in the field of glaucoma is substantial, the pathophysiologic mechanisms causing the disease are not completely understood. A wide variety of animal models have been used to study glaucoma. These include monkeys, dogs, cats, rodents, and several other species. Although these models have provided valuable information about the disease, there is still no ideal model for studying glaucoma due to its complexity. In this paper we present a summary of most of the animal models that have been developed and used for the study of the different types of glaucoma, the strengths and limitations associated with each species use, and some potential criteria to develop a suitable model.