Research Article
Plasmodium Riboprotein PfP0 Induces a Deviant Humoral Immune Response in Balb/c Mice
Table 2
Serum titre and hybridomas obtained following repeated immunizations with various proteins.
| | Immunization number | Number of mice screened | Number of clones screened | Stable clones (specificity) | Serum titre (×104) | Splenic fibrosis |
| | Recombinant PfP0 | | 4 | 16 | ND | − | | − | | 5 | 2 | 120 | 0 | ND | − | | 7 | 3 | 282 | 0 | | + | | 9 | 3 | 478 | 9 (Mouse P0, polyreactive) | | ++ | | 11 | 2 | 571 | 13 (non-PfP0C0, GST) | | +++ |
| | Ant-brain homogenate | | 4 | 1 | 700 | 33 | 5 | − |
| | Drosophila Translin | | 3 | 1 | 290 | 22 | >10 | − |
| | Plasmodium falciparum Phosphofructokinase | | 3 | 1 | 190 | 7 | >50 | − |
| | Plasmodium falciparum enolase | | 5 | 1 | 290 | 10 | >50 | − |
| | Toxoplasma gondii P0 | | 5 | 1 | 300 | >70 | >17 | − |
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ND: not done; −: negative, +: mild, ++: moderate, +++: severe.
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