Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3,-Disinapoyl Sucrose, a Bioactive Compound Isolated from Radix Polygala
Protective effects of DISS on glutamate- (Glu-) induced cytotoxicity in SH-SY5Y cells. (a) Chemical structure of 3,6′-disinapoyl sucrose (DISS). (b) Effects of DISS treatment on SH-SY5Y cells viability decrease induced by glutamate (8 mM) exposure. (c) Effects of DISS treatment on lactate dehydrogenase (LDH) release of SH-SY5Y cell damaged by glutamate. (d) Effect of DISS on glutamate- (Glu-)induced morphological alterations in SH-SY5Y cells. All data were expressed as mean S.D. of three experiments. ##, compared with normal cultures; *, ** compared with Glu alone group. Co: Control; Des: desipramine, which is positive drug.
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