Protection of SH-SY5Y Neuronal Cells from Glutamate-Induced Apoptosis by 3,𝟔^′-Disinapoyl Sucrose, a Bioactive Compound Isolated from Radix Polygala

Figure 1

Protective effects of DISS on glutamate- (Glu-) induced cytotoxicity in SH-SY5Y cells. (a) Chemical structure of 3,6′-disinapoyl sucrose (DISS). (b) Effects of DISS treatment on SH-SY5Y cells viability decrease induced by glutamate (8 mM) exposure. (c) Effects of DISS treatment on lactate dehydrogenase (LDH) release of SH-SY5Y cell damaged by glutamate. (d) Effect of DISS on glutamate- (Glu-)induced morphological alterations in SH-SY5Y cells. All data were expressed as mean± S.D. of three experiments. ^##𝑃<0.01, compared with normal cultures; *𝑃<0.05, **𝑃<0.01 compared with Glu alone group. Co: Control; Des: desipramine, which is positive drug.

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