Soluble Host Defense Lectins in Innate Immunity to Influenza Virus

Table 2

Summary of antiviral activities mediated by animal lectins against IAV.

Lectin^a	HI	NA inhibition	Neutralization	Aggregation	Neutrophil		Selected references
					(i) ↑ uptake	(ii) ↑ H2O2
hSP-D	Yes	Yes	Yes	Yes	Yes	Yes	[42, 60, 61, 87]
hMBL	Yes	Yes	Yes	Yes	Yes	Yes	[60, 85–88]
hCL-K1	—	—	Yes	—	—	—	[96]
bConglutinin	Yes	Yes^b	Yes	Yes	Yes	Yes	[39, 60, 105–107]
bCL-43	Yes	Yes	Yes	No	Yes	No	[60, 103, 115, 145]
bCL-46^c	Yes	—	Yes	Yes	Yes	—	[115, 116]
hGalectin-1	Yes	—	Yes	—	—	—	[28]
hSAP	Yes	—	Yes	—	—	—	[32, 33]

^aData reported for human (h) or bovine (b) lectins as indicated.
^bReported using recombinant chimeric protein containing the N-terminus and collagen domain of rat SP-D expressed with the neck and CRD of conglutinin.
^cReported using CL-46 NCRDs.
—: not reported to date.