Characterization of Flavonol Inhibition of DnaB Helicase: Real-Time Monitoring, Structural Modeling, and Proposed Mechanism
Figure 7
Homology modeling. (a) The three-dimensional models of the hexameric KpDnaB form a ring structure. The monomers are colored differently. ssDNA is colored in black. (b) The structural model of the KpDnaB-ssDNA complex. The NTP-binding site, Walker A and B motifs, is adjacent to the DNA interaction site loop I (green). There are synergistic effects between the nucleotide and ssDNA binding [7]. The Walker A and B motifs are colored in red and blue, respectively. ssDNA is colored in gold.
