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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 758102, 12 pages
Review Article

Toward Personalized Cell Therapies by Using Stem Cells: Seven Relevant Topics for Safety and Success in Stem Cell Therapy

1Post-Graduation Program in Biotechnology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
2Laboratory of Genetics, Department of Biology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora 36036-900, MG, Brazil
3Restorative Dentistry Department, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil

Received 16 June 2012; Accepted 18 October 2012

Academic Editor: Herman S. Cheung

Copyright © 2012 Fernando de Sá Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Stem cells, both embryonic and adult, due to the potential for application in tissue regeneration have been the target of interest to the world scientific community. In fact, stem cells can be considered revolutionary in the field of medicine, especially in the treatment of a wide range of human diseases. However, caution is needed in the clinical application of such cells and this is an issue that demands more studies. This paper will discuss some controversial issues of importance for achieving cell therapy safety and success. Particularly, the following aspects of stem cell biology will be presented: methods for stem cells culture, teratogenic or tumorigenic potential, cellular dose, proliferation, senescence, karyotyping, and immunosuppressive activity.