Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 804592, 7 pages
http://dx.doi.org/10.1155/2012/804592
Clinical Study

Dickkopf-1 Expression Is a Novel Prognostic Marker for Gastric Cancer

Department of Gastroenterology, Huai’an No.1 Hospital, Nanjing Medical University, Huai’an, Jiangsu 223300, China

Received 14 September 2011; Revised 6 November 2011; Accepted 23 November 2011

Academic Editor: Settara Chandrasekharappa

Copyright © 2012 Chengcheng Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C.-W. Tseng, C.-C. Lin, C.-N. Chen, H.-C. Huang, and H.-F. Juan, “Integrative network analysis reveals active microRNAs and their functions in gastric cancer,” BMC Systems Biology, vol. 5, article 99, 2011. View at Publisher · View at Google Scholar
  2. P. Jian, T. Yanfang, Z. Zhuan, W. Jian, Z. Xueming, and N. Jian, “MMP28 (epilysin) as a novel promoter of invasion and metastasis in gastric cancer,” BMC Cancer, vol. 11, article 200, 2011. View at Publisher · View at Google Scholar
  3. A. Atmaca, C. Pauligk, K. Steinmetz, H.-M. Altmannsberger, E. Jäger, and S.-E. Al-Batran, “Prognostic impact of phosphorylated mitogen-activated protein kinase expression in patients with metastatic gastric cancer,” Oncology, vol. 80, no. 1-2, pp. 130–134, 2011. View at Publisher · View at Google Scholar
  4. Y. Katoh and M. Katoh, “Comparative genomics on DKK2 and DKK4 orthologs,” International Journal of Molecular Medicine, vol. 16, no. 3, pp. 477–481, 2005. View at Google Scholar
  5. C. Niehrs, “Function and biological roles of the Dickkopf family of Wnt modulators,” Oncogene, vol. 25, no. 57, pp. 7469–7481, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Kuhnert, C. R. Davis, H. T. Wang et al., “Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 1, pp. 266–271, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Yaccoby, W. Ling, F. Zhan, R. Walker, B. Barlogie, and J. D. Shaughnessy, “Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo,” Blood, vol. 109, no. 5, pp. 2106–2111, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Ogoshi, A. Kasamatsu, M. Iyoda et al., “Dickkopf-1 in human oral cancer,” International Journal of Oncology, vol. 39, no. 2, pp. 329–336, 2011. View at Publisher · View at Google Scholar
  9. R. Feldmann, M. Schierl, A. M. Fink, P.-G. Sator, J. Maiweg, and A. Steiner, “Serum levels of glycoprotein Dickkopf-1 in patients with cutaneous malignant melanoma: a prospective pilot study,” Dermatology, vol. 222, no. 2, pp. 171–175, 2011. View at Publisher · View at Google Scholar
  10. A. M. Mikheev, S. A. Mikheeva, R. Rostomily, and H. Zarbl, “Dickkopf-1 activates cell death in MDA-MB435 melanoma cells,” Biochemical and Biophysical Research Communications, vol. 352, no. 3, pp. 675–680, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Kuphal, S. Lodermeyer, F. Bataille, M. Schuierer, B. H. Hoang, and A. K. Bosserhoff, “Expression of Dickkopf genes is strongly reduced in malignant melanoma,” Oncogene, vol. 25, no. 36, pp. 5027–5036, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Y. Lee, B. He, L. You et al., “Dickkopf-1 antagonizes Wnt signaling independent of β-catenin in human mesothelioma,” Biochemical and Biophysical Research Communications, vol. 323, no. 4, pp. 1246–1250, 2004. View at Publisher · View at Google Scholar
  13. A. M. Mikheev, S. A. Mikheeva, J. P. Maxwell et al., “Dickkopf-1 mediated tumor suppression in human breast carcinoma cells,” Breast Cancer Research and Treatment, vol. 112, no. 2, pp. 263–273, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Wirths, A. Waha, S. Weggen et al., “Overexpression of human Dickkopf-1, an antagonist of wingless/WNT signaling, in human hepatoblastomas and Wilms' tumors,” Laboratory Investigation, vol. 83, no. 3, pp. 429–434, 2003. View at Google Scholar · View at Scopus
  15. M. A. Forget, S. Turcotte, D. Beauseigle et al., “The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types,” British Journal of Cancer, vol. 96, no. 4, pp. 646–653, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Yamabuki, A. Takano, S. Hayama et al., “Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas,” Cancer Research, vol. 67, no. 6, pp. 2517–2525, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Wang and S. Zhang, “Dickkopf-1 is frequently overexpressed in ovarian serous carcinoma and involved in tumor invasion,” Clinical and Experimental Metastasis, vol. 28, no. 6, pp. 581–591, 2011. View at Publisher · View at Google Scholar
  18. H. Shen, Y. Fan, Y. Xi, F. J. Burczynski, P. Li, and Y. Gong, “Increased expression of cystic fibrosis transmembrane conductance regulator in rat liver after common bile duct ligation,” Journal of Cellular Physiology, vol. 203, no. 3, pp. 599–603, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Makino, M. Yamasaki, I. Takemasa et al., “Dickkopf-1 expression as a marker for predicting clinical outcome in esophageal squamous cell carcinoma,” Annals of Surgical Oncology, vol. 16, no. 7, pp. 2058–2064, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Zhou, F. Liu, Q. Xu, and X. Wang, “Analysis of the expression profile of Dickkopf-1 gene in human glioma and the association with tumor malignancy,” Journal of Experimental and Clinical Cancer Research, vol. 29, no. 1, article 138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. L. H. Weng, C. J. Wang, J. Y. Ko, Y. C. Sun, Y. S. Su, and F. S. Wang, “Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint,” Osteoarthritis and Cartilage, vol. 17, no. 7, pp. 933–943, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. J. M. González-Sancho, O. Aguilera, J. M. García et al., “The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer,” Oncogene, vol. 24, no. 6, pp. 1098–1103, 2005. View at Publisher · View at Google Scholar
  23. A. M. Mikheev, S. A. Mikheeva, B. Liu, P. Cohen, and H. Zarbl, “A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation,” Carcinogenesis, vol. 25, no. 1, pp. 47–59, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Shou, F. Ali-Osman, A. S. Multani, S. Pathak, P. Fedi, and K. S. Srivenugopal, “Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA,” Oncogene, vol. 21, no. 6, pp. 878–889, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Sato, H. Suzuki, M. Toyota et al., “Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors,” Carcinogenesis, vol. 28, no. 12, pp. 2459–2466, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. L. S. Shi, G. Huang, B. Yu, and X. Q. Wen, “Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer,” Clinical Chemistry, vol. 55, no. 9, pp. 1656–1664, 2009. View at Publisher · View at Google Scholar · View at Scopus