Figure 3: Agonistic effects of physiologically active substances on MRGPRD. Representative dose-dependent curves of physiologically active substances in (a) GTPγS binding assay, (b) calcium flux assay, and (c) IP assay are shown. Each value expresses the percentage of control with maximum efficacy in each assay. βAla on MRGPRD (open diamond), βAIBA on MRGPRD (open square), GABA on MRGPRD (open triangle). DES on MRGPRD (open circle), βAla on mock (closed diamond), βAIBA on mock (closed square), GABA on mock (closed triangle), DES on mock (closed circle).