Development of ^𝟗𝟗𝐦𝐓𝐜-N4-NIM for Molecular Imaging of Tumor Hypoxia

Table 1

Biodistribution of  ^99mTc-N4 in mammary tumor-bearing rats.

% of injected dose per gram of tissue weight
(𝑛=3/time, interval, iv)
	30 min	120 min	240 min
Blood	0.23±0.009	0.04±0.002	0.02±0.002
Heart	0.07±0.005	0.01±0.001	0.01±0.000
Lung	0.20±0.011	0.05±0.002	0.03±0.001
Thyroid	0.25±0.011	0.03±0.002	0.02±0.001
Pancreas	0.07±0.007	0.02±0.002	0.02±0.001
Liver	2.98±0.083	1.14±0.018	0.79±0.026
Spleen	0.35±0.026	0.37±0.007	0.39±0.020
Kidney	2.56±0.101	1.11±0.045	0.65±0.028
Stomach	0.12±0.005	0.02±0.001	0.01±0.000
Intestine	0.25±0.004	0.39±0.048	0.14±0.003
Uterus	0.16±0.014	0.02±0.001	0.01±0.001
Tumor	0.09±0.004	0.03±0.003	0.02±0.001
Muscle	0.05±0.002	0.01±0.000	0.01±0.000
Bone	0.07±0.001	0.02±0.001	0.01±0.000
Brain	0.01±0.000	0.00±0.000	0.00±0.000
Tumor/blood	0.40±0.002	0.78±0.044	0.70±0.008
Tumor/muscle	1.96±0.015	5.32±0.402	3.35±0.147
Tumor/brain	6.19±0.365	11.06±0.667	11.93±0.675

Value shown represents the mean ± standard deviation of data from 3 animals.