Development of ^𝟗𝟗𝐦𝐓𝐜-N4-NIM for Molecular Imaging of Tumor Hypoxia

Table 2

Biodistribution of  ^99mTc-N₄-NIM in mammary tumor-bearing rats.

% of injected dose per gram of tissue weight
(𝑛=3/time, interval, iv)
	30 min	2 h	4 h
Blood	0.76±0.06	0.20±0.01	0.16±0.01
Heart	0.26±0.03	0.07±0.01	0.04±0.00
Lung	0.58±0.06	0.17±0.00	0.10±0.00
Thyroid	0.71±0.06	0.17±0.01	0.08±0.00
Pancreas	0.22±0.03	0.06±0.00	0.04±0.01
Liver	0.88±0.05	0.84±0.03	0.51±0.02
Spleen	0.74±0.13	0.42±0.01	0.70±0.02
Kidney	4.92±0.89	4.42±0.06	1.33±0.10
Stomach	0.37±0.04	0.09±0.01	0.03±0.00
Intestine	0.33±0.04	0.15±0.07	0.04±0.01
Uterus	0.61±0.16	0.20±0.11	0.08±0.01
Tumor	0.52±0.02	0.20±0.00	0.08±0.00
Muscle	0.18±0.01	0.04±0.00	0.02±0.00
Bone	0.22±0.08	0.14±0.02	0.03±0.00
Brain	0.04±0.00	0.01±0.00	0.01±0.00
Tumor/blood	0.69±0.02	1.01±0.05	0.98±0.06
Tumor/muscle	2.86±0.19	5.69±0.40	4.88±0.56
Tumor/brain	12.74±2.26	15.51±2.16	15.10±2.47

Values shown represent the mean ± standard deviation of data from 3 animals.