Table of Contents Author Guidelines Submit a Manuscript
Corrigendum

A corrigendum for this article has been published. To view the corrigendum, please click here.

Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 853879, 7 pages
http://dx.doi.org/10.1155/2012/853879
Research Article

Molecular Characterization of a Fully Human Chimeric T-Cell Antigen Receptor for Tumor-Associated Antigen EpCAM

1Department of Biochemistry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
2Center for Advanced Molecular Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
3School of Nursing, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan

Received 15 November 2011; Revised 7 January 2012; Accepted 29 January 2012

Academic Editor: Jeffrey A. Frelinger

Copyright © 2012 Naoto Shirasu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Jena, G. Dotti, and L. J. N. Cooper, “Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor,” Blood, vol. 116, no. 7, pp. 1035–1044, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. V. Marcu-Malina, S. Van Dorp, and J. Kuball, “Re-targeting T-cells against cancer by gene-transfer of tumor-reactive receptors,” Expert Opinion on Biological Therapy, vol. 9, no. 5, pp. 579–591, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Loskog, V. Giandomenico, C. Rossig, M. Pule, G. Dotti, and M. K. Brenner, “Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells,” Leukemia, vol. 20, no. 10, pp. 1819–1828, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. C. M. Kowolik, M. S. Topp, S. Gonzalez et al., “CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells,” Cancer Research, vol. 66, no. 22, pp. 10995–11004, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. J. S. de Bono, S. Y. Rha, J. Stephenson et al., “Phase I trial of a murine antibody to MUC1 in patients with metastatic cancer: evidence for the activation of humoral and cellular antitumor immunity,” Annals of Oncology, vol. 15, no. 12, pp. 1825–1833, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Kuroki, H. Yamada, H. Shibaguchi et al., “Preparation of human IgG and IgM monoclonal antibodies for MK-1/Ep-CAM by using human immunoglobulin gene-transferred mouse and gene cloning of their variable regions,” Anticancer Research, vol. 25, no. 6 A, pp. 3733–3739, 2005. View at Google Scholar · View at Scopus
  7. I. Ishida, K. Tomizuka, H. Yoshida et al., “Production of human monoclonal and polyclonal antibodies in TransChromo animals,” Cloning and Stem Cells, vol. 4, no. 1, pp. 91–102, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Armstrong and S. L. Eck, “EpCAM: a new therapeutic target for an old cancer antigen,” Cancer Biology and Therapy, vol. 2, no. 4, pp. 320–326, 2003. View at Publisher · View at Google Scholar
  9. F. Le Naour and M. Zoller, “The tumor antigen EpCAM: tetraspanins and the tight junction protein claudin-7, new partners, new functions,” Frontiers in Bioscience, vol. 13, pp. 5847–5865, 2008. View at Google Scholar · View at Scopus
  10. B. Al-Lazikani, A. M. Lesk, and C. Chothia, “Standard conformations for the canonical structures of immunoglobulins,” Journal of Molecular Biology, vol. 273, no. 4, pp. 927–948, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Shirasu, H. Shibaguci, M. Kuroki, H. Yamada, and M. Kuroki, “Construction and molecular characterization of human chimeric T-cell antigen receptors specific for carcinoembryonic antigen,” Anticancer Research, vol. 30, no. 7, pp. 2731–2738, 2010. View at Google Scholar · View at Scopus
  12. J. D. Marks and A. Bradbury, “PCR cloning of human immunoglobulin genes,” Methods in Molecular Biology, vol. 248, pp. 117–134, 2004. View at Google Scholar · View at Scopus
  13. L. J. Holt, K. Büssow, G. Walter, and I. M. Tomlinson, “By-passing selection: direct screening for antibody-antigen interactions using protein arrays,” Nucleic Acids Research, vol. 28, no. 15, p. E72, 2000. View at Google Scholar · View at Scopus
  14. S. C. Bunnell, V. A. Barr, C. L. Fuller, and L. E. Samelson, “High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates,” Science's STKE, vol. 2003, no. 177, p. PL8, 2003. View at Google Scholar · View at Scopus
  15. W. L. Carroll, E. Mendel, and S. Levy, “Hybridoma fusion cell lines contain an aberrant kappa transcript,” Molecular Immunology, vol. 25, no. 10, pp. 991–995, 1988. View at Google Scholar · View at Scopus
  16. L. E. Samelson, “Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins,” Annual Review of Immunology, vol. 20, pp. 371–394, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. P. E. Love and S. M. Hayes, “ITAM-mediated signaling by the T-cell antigen receptor,” Cold Spring Harbor Perspectives in Biology, vol. 2, no. 6, p. a002485, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Barda-Saad, A. Braiman, R. Titerence, S. C. Bunnell, V. A. Barr, and L. E. Samelson, “Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton,” Nature Immunology, vol. 6, no. 1, pp. 80–89, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. B. B. Au-Yeung, S. Deindl, L. Y. Hsu et al., “The structure, regulation, and function of ZAP-70,” Immunological Reviews, vol. 228, no. 1, pp. 41–57, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Saito and T. Yokosuka, “Immunological synapse and microclusters: the site for recognition and activation of T cells,” Current Opinion in Immunology, vol. 18, no. 3, pp. 305–313, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. S. C. Bunnell, A. L. Singer, D. I. Hong et al., “Persistence of cooperatively stabilized signaling clusters drives T-cell activation,” Molecular and Cellular Biology, vol. 26, no. 19, pp. 7155–7166, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. D. L. Porter, B. L. Levine, M. Kalos, A. Bagg, and C. H. June, “Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia,” The New England Journal of Medicine, vol. 365, no. 8, pp. 725–733, 2011. View at Publisher · View at Google Scholar