The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats

Table 1

The main pharmacokinetic parameters of cortisone in two groups 𝑛=6.

Pharmacokinetic parameters	E	E + GA
𝑡1/2𝛽/min	38.182 ± 12.994	54.804 ± 11.394*
CL/F/L·min^−1·kg^−1	0.144 ± 0.029	0.067 ± 0.004**
AUC(0-𝑡)/mg·min·L^−1	139.147 ± 27.749	281.729 ± 19.740**
AUC(0-∞)/mg·min·L^−1	144.295 ± 32.099	297.792 ± 20.450**
𝐶max/mg·L^−1	2.401 ± 0.242	3.516 ± 0.223**

* 𝑃<0.05; **𝑃<0.01 in comparison to E.