Altered Polarization, Morphology, and Impaired Innate Immunity Germane to Resident Peritoneal Macrophages in Mice with Long-Term Type 2 Diabetes

Figure 2

Decreased phagocytosis of polystyrenelatex beads by F4/80⁺ RPMs in 5-month diabetic mice. One representative experiment of 4 detected by FCM showing RPMs from normal mice (b) and db/db mice (d) after incubated with fluorescence-modified polystyrenelatex beads for 2 h at 37°C, wheals the control from normal mice (a) and db/db mice (c) were incubated at 4°C. The average phagocytic rate (e) and MIF (f) of four independent experiments were quantified. ***P < 0.001 between the indicated groups.

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