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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 876458, 5 pages
http://dx.doi.org/10.1155/2012/876458
Research Article

Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts

1Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
2Medicinal Plants Division, Forest Research Institute of Malaysia (FRIM), Kepong, 52109 Kuala Lumpur, Malaysia
3Department of Pharmacy, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia

Received 29 July 2011; Revised 20 January 2012; Accepted 21 January 2012

Academic Editor: Masa-Aki Shibata

Copyright © 2012 Khalijah Awang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 2 4 . 5 ± 3 . 0  mm Hg at a 3 mg dose and also reduced heart rate by up to 4 9 . 5 ± 1 1 . 4  beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.