Roles of p53 in Various Biological Aspects of Hematopoietic Stem Cells

Figure 4

Schematic diagram of p53 roles in HSCs. p53 is involved in the control of response to DNA damage, self-renewal, quiescence, apoptosis, senescence, leukemogenesis, and plasticity in HSCs. Lines with an arrowhead indicate promotion and lines with a bar inhibition in steady state (black) or stress conditions (red).