An In Vivo Rabbit Model for the Evaluation of Antimicrobial Peripherally Inserted Central Catheter to Reduce Microbial Migration and Colonization as Compared to an Uncoated PICC
Figure 4
Representative digital micrographs (100x magnification) taken during the histological review of tissue segments from animal 10. (a) Test catheter 3, segment 5: neutrophils and/or macrophages are present, with inflammation in the lumen, (b) test catheter 3, segment 7: neutrophils and/or macrophages are present, with inflammation in the lumen. There is an inner layer which would have been adjacent to the catheter which is composed of well-vascularised immature connective tissue with a mild inflammatory reaction. There is also an outer layer of mature, well-organized, and uninflamed fibrous connective tissue. (c) Test catheter 3, segment 5: neutrophils and/or macrophages are present; inflammation extends to include the subcutis outside the connective tissue tunnel. (d) Control catheter 3, segment 5: neutrophils and/or macrophages are present, with inflammation in the lumen. (e) Control catheter 3, segment 7: neutrophils and/or macrophages are present; inflammation extends to include the subcutis outside the connective tissue tunnel. (f) Control catheter 3, segment 9: neutrophils, macrophages and lymphocytes are present; inflammation extends to include the subcutis outside the connective tissue tunnel. There is a thick necrotic mass of debris in lumen, with more general inflammation of wall.
