An In Vivo Rabbit Model for the Evaluation of Antimicrobial Peripherally Inserted Central Catheter to Reduce Microbial Migration and Colonization as Compared to an Uncoated PICC
Table 2
Tissue (CFU/g) Log reduction summary tables for day 21. Log reduction values higher than 4 are bold and underlined.
(a) For pairwise comparison, the mean Log10 CFU/g recovered from the three replicates of test articles/rabbit was subtracted from the mean Log10 CFU/g recovered from the three replicates of control articles/rabbit per segment
Sample location
Sample no.
3
4
6
8
10
Day
Rabbit no.
Log (pairwise comparison)
21
1
0.81
4.28
6.03
289
2.44
0.50
0.05
0.00
0.31
0.83
21
4
−2.46
−1.54
−0.44
1.93
1.18
0.18
0.35
0.86
0.37
0.59
21
7
2.90
3.08
1.87
1.70
3.22
0.13
0.14
0.37
0.50
0.12
21
9
1.23
1.10
1.48
0.00
1.59
0.37
0.37
0.37
N/A
0.37
21
10
5.30
3.68
3.73
5.02
4.48
0.00
0.13
0.14
0.01
0.01
(b) For test article log reduction, the mean Log10 CFU/g recovered from the three replicates of test articles/rabbit was subtracted from the mean Log10 CFU from the initial inoculum counts that were exposed to the catheters at implantation
Sample location
Sample no.
3
4
6
8
10
Day
Rabbit no.
Test article Log (based on initial inoculum)
21
1
2.62
5.67
6.86
5.55
5.72
0.50
0.05
0.00
0.31
0.83
21
4
1.49
2.53
4.41
6.86
5.38
0.18
0.35
0.86
0.37
0.59
21
7
6.86
6.86
6.86
5.29
6.86
0.13
0.14
0.37
0.50
0.12
21
9
6.86
6.86
6.86
6.86
6.86
0.37
0.37
0.37
N/A
0.37
21
10
6.86
6.86
6.86
6.86
6.86
0.00
0.13
0.14
0.01
0.01
(c) For control article log reduction, the mean Log10 CFU/g recovered from the three replicates of control articles/rabbit was subtracted from the mean Log10 CFU from the initial inoculum counts that were exposed to the catheters at implantation
