An In Vivo Rabbit Model for the Evaluation of Antimicrobial Peripherally Inserted Central Catheter to Reduce Microbial Migration and Colonization as Compared to an Uncoated PICC
Table 4
Tissue (CFU/g) Log reduction summary tables for day 30. Log reduction values higher than 4 are bold and underlined.
(a) For pairwise comparison, the mean Log10 CFU/g recovered from the three replicates of test articles/rabbit was subtracted from the mean Log10 CFU/g recovered from the three replicates of control articles/rabbit per segment
Sample location
Sample no.
3
4
6
8
10
Day
Rabbit no.
Log (pairwise comparison)
30
2
0.98
0.00
0.00
0.00
−0.74
0.37
0.00
0.00
0.00
0.76
30
3
−1.05
2.43
1.16
2.48
4.52
0.37
0.13
0.37
0.12
0.00
30
5
−2.57
2.18
2.41
1.06
1.04
0.12
0.12
0.12
0.37
0.37
30
6**
3.91
0.00
0.00
0.00
0.00
N/A
N/A
N/A
N/A
N/A
30
8
4.90
2.24
3.70
3.68
5.18
0.01
0.37
0.14
0.13
0.00
(b) For test article log reduction, the mean Log10 CFU/g recovered from the three replicates of test articles/rabbit was subtracted from the mean Log10 CFU from the initial inoculum counts that were exposed to the catheters at implantation
Sample location
Sample no.
3
4
6
8
10
Day
Rabbit no.
Test article Log (based on initial inoculum)
30
2
6.86
6.86
6.86
6.86
5.02
0.37
0.00
0.00
0.00
0.76
30
3
5.81
6.86
6.86
6.86
6.86
0.37
0.13
0.37
0.12
0.00
30
5
4.28
6.86
6.86
6.86
6.86
0.12
0.12
0.12
0.37
0.37
30
6**
6.86
6.86
6.86
6.86
6.86
N/A
N/A
N/A
N/A
N/A
30
8
6.86
6.86
6.86
6.86
6.86
0.01
0.37
0.14
0.13
0.00
(c) For control article log reduction, the mean Log10 CFU/g recovered from the three replicates of control articles/rabbit was subtracted from the mean Log10 CFU from the initial inoculum counts that were exposed to the catheters at implantation
Sample location
Sample no.
3
4
6
8
10
Day
Rabbit no.
Control article Log (based on initial inoculum)
30
2
5.87
6.86
6.86
6.86
5.76
0.37
0.00
0.00
0.00
0.76
30
3
6.86
4.42
5.70
4.37
2.34
0.37
0.13
0.37
0.12
0.00
30
5
6.86
4.67
4.44
5.80
5.81
0.12
0.12
0.12
0.37
0.37
30
6**
2.95
6.86
6.86
6.86
6.86
N/A
N/A
N/A
N/A
N/A
30
8
1.95
4.62
3.15
3.18
1.67
0.01
0.37
0.14
0.13
0.00
**indicates that control tunnels 1 and 3 on rabbit 6 were not available for analysis.