Contribution of Yeast Models to Neurodegeneration Research

Table 1

Proteins associated with human neurodegenerative disorders studied in yeast.

Disease	Protein(s) involved	Yeast orthologue	References
Batten’s disease	CLN3	YHC3/BTN1	[16]
Friedreich’s Ataxia	Frataxin	YFH1	[12, 13]
Ataxia-telangiectasia	ATM	TEL1, MEC1	[19, 20]
Niemann-Pick disease	NPC1	NCR1	[17, 18]
Hereditary Spastic Paraplegia	mAAA-proteases	mAAA proteases	[21]
	(Afg312 and paraplegin)	(Yta10 and Yta12)
Creutzfeldt-Jakob disease	PrP	—	[23]
Amyotrophic lateral sclerosis	SOD1	SOD1	[25]
	TDP-43	—	[27]
	FUS/TLS	—	[29, 30]
Parkinson’s disease	α-synuclein	—	[31]
	Lrrk2	—	[32]
Alzheimer’s disease	Amyloid β	—	[33, 34]
	tau	—	[35]
Huntington’s disease	Huntingtin	—	[41]

—: No orthologue.