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Journal of Biomedicine and Biotechnology
Volume 2012, Article ID 980458, 6 pages
http://dx.doi.org/10.1155/2012/980458
Review Article

Colorectal Cancer Chemoprevention by Mesalazine and Its Derivatives

Department of Internal Medicine, University of Rome “Tor Vergata” 1-00133, Rome, Italy

Received 13 March 2012; Accepted 20 April 2012

Academic Editor: Amr Amin

Copyright © 2012 Carmine Stolfi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with inflammatory bowel disease (IBD) face an increased lifetime risk of developing colorectal cancer (CRC). Independent factors associated with increased risk include long disease duration, extensive colonic involvement, young age at onset of IBD, severity of inflammation, primary sclerosing cholangitis, backwash ileitis, and a family history of CRC, thus emphasising the role of intestinal inflammation as an underlying mechanism. This notion is also supported by the demonstration that the use of certain drugs used to attenuate the ongoing mucosal inflammation, such as mesalazine, seems to associate with a reduced incidence of colitis-associated CRC. In the last decade, work from many laboratories has contributed to delineate the mechanisms by which mesalazine alters CRC cell behaviour. In this paper, we review the available experimental data supporting the ability of mesalazine and its derivatives to interfere with intracellular signals involved in CRC cell growth.