1,25-Dihydroxyvitamin D3 Inhibits the RANKL Pathway and Impacts on the Production of Pathway-Associated Cytokines in Early Rheumatoid Arthritis

<table>The levels of IL-4 after treatment with 1,25(OH)<sub>2</sub>D<sub>3</sub>,   MTX, and 1,25(OH)<sub>2</sub>D<sub>3</sub> plus MTX in RA patients. The RA patients’ PBMCs are treated with either anti-CD3/CD28, 1,25(OH)<sub>2</sub>D<sub>3</sub> and MTX at various concentrations, or the combination of 1,25(OH)<sub>2</sub>D<sub>3</sub> and MTX (D2M2 group). 1,25(OH)<sub>2</sub>D<sub>3</sub>, MTX and 1,25(OH)<sub>2</sub>D<sub>3</sub> plus MTX up-regulated the level of IL-4; however, there was no significant difference in IL-4 expression in the groups of 1,25(OH)<sub>2</sub>D<sub>3</sub>,   MTX but there was significant difference in D2 M2 group (<svg height="11.375" id="M30" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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BioMed Research International

fig7

Figure 7

Figure 7: 1,25-Dihydroxyvitamin D3 Inhibits the RANKL Pathway and Impacts on the Production of Pathway-Associated Cytokines in Early Rheumatoid Arthritis 

Figure 7 | 1,25-Dihydroxyvitamin D3 Inhibits the RANKL Pathway and Impacts on the Production of Pathway-Associated Cytokines in Early Rheumatoid Arthritis 