Clinical Study
Cardiovascular and Renal Effects of Bromocriptine in Diabetic Patients with Stage 4 Chronic Kidney Disease
Table 2
Echocardiography and biochemical parameters in patients receiving bromocriptine (BEC) or placebo (PBO).
| | Variable | Baseline | 3 months | 6 months | value | | BEC | PBO | BEC | PBO | BEC | PBO |
| | Echocardiography data | | | | | | | | | LVM (g) | 241.9 ± 15.5 | 237.6 ± 16.3 | 207.1 ± 14.0 | 248.6 ± 16.3 | 207.6 ± 17.0 | 260.4 ± 14.4 | 0.003 | | LVMI (g/m2) | 143.9 ± 6.2 | 146.2 ± 7.4 | 123.5 ± 5.6 | 152.2 ± 7.3 | 123.2 ± 8.8 | 158.2 ± 6.5 | 0.001 | | LVDD (mm) | 42.4 ± 1.5 | 41.1 ± 1.3 | 41.4 ± 1.4 | 42.7 ± 1.2 | 41.4 ± 1.6 | 43.8 ± 1.2 | NS | | LVSD (mm) | 26.21 ± 4.0 | 26.6 ± 5.9 | 26.72 ± 5.1 | 25.5 ± 6.1 | 26.22 ± 5.8 | 24.8 ± 5.8 | NS | | LV EF (%) | 72.5 ± 12.8 | 73.4 ± 12 | 71.7 ± 13.1 | 73.1 ± 13 | 73.0 ± 11.9 | 75.4 ± 11 | NS | | LVPWT (mm) | 14.7 ± 0.4 | 13.6 ± 0.5 | 13.2 ± 0.5 | 13.8 ± 0.4 | 13.2 ± 0.5 | 14.2 ± 0.4 | 0.042 | | IVST (mm) | 14.1 ± 0.4 | 13.6 ± 0.5 | 13.6 ± 0.5
| 13.8 ± 0.4 | 13.1 ± 0.3 | 14.2 ± 0.4 | 0.001 | | Biochemical variables | | | | | | | | | S-Cr (mmol/L) | 288.88 ± 17.6 | 280.22 ± 17.6 | 291.72 ± .26.5 | 322.6 ± 73.3 | 309.4 ± 26.5 | 362.4 ± 17.6 | 0.01 | | CrCl (mL/min) | 16.85 ± 7.71 | 17.75 ± 4.34 | 17.06 ± 8.79 | 14.30 ± 3.81 | 17.53 ± 10.37 | 11.89 ± 3.58 | 0.03 | | Cystatin C (mg/L) | 3.03 ± 0.95 | 3.03 ± 0.74 | 3.05 ± 0.95
| 3.43 ± 0.96 | 3.58 ± 1.1 | 3.48 ± 0.84 | 0.05 | | GFRcyst (mL/min) | 30.1 ± 11.0 | 30.3 ± 8.2 | 29.3 ± 7.9 | 28.0 ± 6.3 | 29.4 ± 14.3 | 26.9 ± 4.5 | NS | | Glucose (mmol/L) | 8.16 ± .0.95 | 7.23 ± 0.93 | 6.50 ± 0.66.
| 7.65 ± 0.16 | 5.83 ± 0.38 | 5.88 ± 0.44 | NS | | Cholesterol (mmol/L) | 5.65 ± 0.33 | 5.82 ± 0.48 | 4.85 ± 0.33 | 5.48 ± 0.38 | 4.53 ± 0.33 | 5.18 ± 0.33 | 0.01 | | Triglycerides (mmol/L) | 2.39 ± 0.22 | 2.25 ± 0.32 | 2.10 ± 0.22
| 2.06 ± 0.22 | 2.14 ± 0.28 | 2.21 ± 0.28 | NS | | Prolactin (mmol/L) | 7.4 ± 3.2 | 3.6 ± 0.4 | 5.0 ± 2.5 | 4.4 ± 0.7 | 3.3 ± 1.1 | 6.8 ± 1.5 | 0.026 | Aldosterone (mmol/L)
| 485 ± 319 | 577 ± 557 | 594 ± 402 | 594 ± 446 | 586 ± 427 | 510 ± 369 | NS | | NT-proBNP (pmol/mL) | 0.5429 ± 0.74
| 0.3743 ± 0.34
| 0.3771 ± 0.34
| 0.6257 ± 1.05 | 0.3914 ± 0.20
| 0.6921 ± 0.90 | 0.01 |
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LVM: left ventricle mass; LVMI: left ventricle mass index; LVDD: left ventricle diastolic diameter; LVSD: left ventricle systolic diameter; LV EF: left ventricle ejection fraction; LVPWT: left ventricle posterior wall thickness; IVST: interventricular septum thickness. S-Cr: serum creatinine; CrCl: creatinine clearance; GFRcyst: glomerular filtration rate calculated by serum cystatin C.
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