Immune Parameters in The Prognosis and Therapy Monitoring of Cutaneous Melanoma Patients: Experience, Role, and Limitations

Figure 1

Interrelation mediated by humoral factors between keratinocytes and T cells. Keratinocytes up-regulates T cell functions by IL-1, GM-CSF, TNF-alpha, IL-6, 7, 12, 15, and 18 and down-regulates them by IL-1Ra, IL-10, α-MSH, CXCL10, Contra IL-1, and PGE2. T cell produces IFN-alpha, IL-17, and IL-4 that influences keratinocyte’s functions. Keratinocyte’s chemoattractant cytokines influences T cell trafficking: IL-1, IL-8, CCL27, CCL5, CCL17, CXCL10, MIG, IP9, and CCL20 [5].