Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 132793, 8 pages
http://dx.doi.org/10.1155/2013/132793
Research Article

Interferon-α Enhances 5′-Deoxy-5-Fluorouridine-Induced Apoptosis by ERK-Dependant Upregulation of Thymidine Phosphorylase

1Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China
2Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, Liaoning 110001, China

Received 18 March 2013; Revised 16 July 2013; Accepted 19 July 2013

Academic Editor: Yukio Kageyama

Copyright © 2013 Yike Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Kamangar, G. M. Dores, and W. F. Anderson, “Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world,” Journal of Clinical Oncology, vol. 24, no. 14, pp. 2137–2150, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Liakakos and D. H. Roukos, “More controversy than ever—challenges and promises towards personalized treatment of gastric cancer,” Annals of Surgical Oncology, vol. 15, no. 4, pp. 956–960, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. A. F. C. Okines, A. R. Norman, P. McCloud, Y. K. Kang, and D. Cunningham, “Meta-analysis of the REAL-2 and ML17032 trials: evaluating capecitabine-based combination chemotherapy and infused 5-fluorouracil-based combination chemotherapy for the treatment of advanced oesophago-gastric cancer,” Annals of Oncology, vol. 20, no. 9, pp. 1529–1534, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Di Gennaro, G. Piro, M. I. Chianese et al., “Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase,” The British Journal of Cancer, vol. 103, no. 11, pp. 1680–1691, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Ait-Tihyaty, Z. Rachid, C. Mihalcioiu, and B. J. Jean-Claude, “Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5′-DFUR, the bioactive metabolite of Xeloda,” Breast Cancer Research and Treatment, vol. 133, no. 1, pp. 217–226, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Shindoh, K. Nakano, T. Yoshida, and M. Ishigai, “Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans—toxicological implications,” Journal of Toxicological Sciences, vol. 36, no. 4, pp. 411–422, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Adalid-Peralta, V. Godot, C. Colin et al., “Stimulation of the primary anti-HIV antibody response by IFN-α in patients with acute HIV-1 infection,” Journal of Leukocyte Biology, vol. 83, no. 4, pp. 1060–1067, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Négrier, G. Gravis, D. Pérol et al., “Temsirolimus and bevacizumab, or sunitinib, or interferon α and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): a randomised phase 2 trial,” The Lancet Oncology, vol. 12, no. 7, pp. 673–680, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Hansson, S. Aamdal, L. Bastholt et al., “Two different durations of adjuvant therapy with intermediate-dose interferon α-2b in patients with high-risk melanoma (Nordic IFN trial): a randomised phase 3 trial,” The Lancet Oncology, vol. 12, no. 2, pp. 144–152, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Simonsson, T. Gedde-Dahl, B. Markevärn et al., “Combination of pegylated IFN-α2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia,” Blood, vol. 118, no. 12, pp. 3228–3235, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Hodson, S. Crichton, S. Montoto et al., “Use of zidovudine and interferon α with chemotherapy improves survival in both acute and lymphoma subtypes of adult T-cell leukemia/lymphoma,” Journal of Clinical Oncology, vol. 29, no. 35, pp. 4696–4701, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. K. H. Link, M. Kornmann, L. Staib, M. Redenbacher, M. Kron, and H. G. Beger, “Increase of survival benefit in advanced resectable colon cancer by extent of adjuvant treatment: results of a randomized trial comparing modulation of 5-FU + levamisole with folinic acid or with interferon-α,” Annals of Surgery, vol. 242, no. 2, pp. 178–187, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. S. Xiao, Z. Y. Tang, J. Fan et al., “Interferon-α 2a up-regulated thymidine phosphorylase and enhanced antitumor effect of capecitabine on hepatocellular carcinoma in nude mice,” Journal of Cancer Research and Clinical Oncology, vol. 130, no. 9, pp. 546–550, 2004. View at Google Scholar · View at Scopus
  14. S. Ikemoto, K. Sugimura, N. Yoshida, K. Kuratsukuri, S. Wada, and T. Nakatani, “Comparative antitumor activity of 5-fluorouracil and 5′-deoxy-5- fluorouridine in combination with interferon-α in renal cell carcinoma cell lines,” Urologia Internationalis, vol. 73, no. 4, pp. 348–353, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. L. C. Chen, H. P. Liu, H. P. Li et al., “Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells,” Oncogene, vol. 28, no. 17, pp. 1904–1915, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Saito, K. Khan, S. Z. Yu et al., “The predictive and therapeutic value of thymidine phosphorylase and dihydropyrimidine dehydrogenase in capecitabine (Xeloda)-based chemotherapy for head and neck cancer,” Laryngoscope, vol. 119, no. 1, pp. 82–88, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Tsuneyoshi, M. Haraguchi, Z. Hongye et al., “Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5′-DFUR cytotoxicity,” Cancer Letters, vol. 244, no. 2, pp. 239–246, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. L. C. Chen, C. Hsueh, N. M. Tsang et al., “Heterogeneous ribonucleoprotein K and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinoma,” Clinical Cancer Research, vol. 14, no. 12, pp. 3807–3813, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Yano, S. Ogasawara, S. Momosaki et al., “Growth inhibitory effects of pegylated IFN α-2b on human liver cancer cells in vitro and in vivo,” Liver International, vol. 26, no. 8, pp. 964–975, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Makower, S. Wadler, H. Haynes, and E. L. Schwartz, “Interferon induces thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in vivo,” Clinical Cancer Research, vol. 3, no. 6, pp. 923–929, 1997. View at Google Scholar · View at Scopus
  21. G. Li, S. Kawakami, Y. Kageyama, C. Yan, K. Saito, and K. Kihara, “IFNγ-induced up-regulation of PD-ECGF/TP enhances the cytotoxicity of 5-fluorouracil and 5′-deoxy-5-fluorouridine in bladder cancer cells,” Anticancer Research, vol. 22, no. 5, pp. 2607–2612, 2002. View at Google Scholar · View at Scopus
  22. K. W. Zhao, D. Li, Q. Zhao et al., “Interferon-α-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cδ and JNK,” The Journal of Biological Chemistry, vol. 280, no. 52, pp. 42707–42714, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. J. C. Ko, M. S. Tsai, Y. F. Chiu, S. H. Weng, Y. H. Kuo, and Y. W. Lin, “Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells,” Journal of Pharmacology and Experimental Therapeutics, vol. 338, no. 1, pp. 184–194, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Qu, Y. Li, J. Liu et al., “Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation,” Molecular and Cellular Biochemistry, vol. 340, no. 1-2, pp. 107–114, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Panaretakis, L. Hjortsberg, K. P. Tamm, A. C. Björklund, B. Joseph, and D. Grandér, “Interferon α induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin,” Molecular Biology of the Cell, vol. 19, no. 1, pp. 41–50, 2008. View at Publisher · View at Google Scholar · View at Scopus